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Hank balanced salt solution added with HEPES(cas 7365-45-9)

To observe the effects of different concentrations of oxymetazoline hydrochloride on the cilia movement of human catechial mucosa in vitro.

Methods: The tissue culture was used to observe the effect of Hank balanced salt solution added with HEPES(cas 7365-45-9), 0.25,0.50,1.00 and 2.00g /L oxymetazoline hydrochloride, cell cilia swing frequency, and paired analysis.

Results: (1) There was no significant change in CBF within 20 min after HBSS (F = 0.098, P = 1.00); (2) 0.25g /L oxymetazoline hydrochloride group had no significant change with CBF before 20 min (F = 0.124, P = 1.00); (3)0.50g /L Hydroxymazoline hydrochloride was similar to 1.00g /L oxymetazoline hydrochloride, CBF increased slightly and peaked in 1 ~ 2min (P = 0.05, P <0.05), and the CBF began to decrease slowly after 3 ~ 4 min, and reached the lowest value at the end of the measurement, but the difference was not significant (0.50 g /L) (F = 3.78, P = 0.00); (4)4.00g /L oxymetazoline hydrochloride group was significantly higher than that in the control group (P <0.05), and the difference was statistically significant (P = 0.00) (F = 0.69, P = 0.00); (5) The maximal increase of the CBF in the first 3 min was statistically significant (F = 0.85, P = 0.00), and the difference was not statistically significant (P = 0.50). The maximum decrease in drug weight was significantly lower at 1.00 and 2.00 g / L CBF, with a statistically significant difference (F = 23.74, P = 0.00).

Conclusion: Methomizole hydrochloride of 0.25 ~ 2.00g /L has a certain concentration-dependent inhibition on the cilia movement of human nasal ciliated cells in vitro, and the inhibitory effect increases with the increase of drug concentration. 0.50g /L oxymetazoline hydrochloride may be more suitable for clinical use.

 

 

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