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Use MES(cas 4432-31-9) buffer solution

The present invention discloses a method for preparing an anticoagulant material for improving the surface anticancer agent surface modification of an anticoagulant, comprising the steps of dissolving bivalirudin in 0.1 g / Ml-10 mg / mL solution; WSC composition solution is 9.76 mg / mL MES(cas 4432-31-9) buffer solution, 1 mg / mL 1-ethyl-3- (3-dimethylaminopropyl) Imine and 0.24 mg / mL N-hydroxysuccinimide to give a bivalirudin-WSC solution. The surface of the biomedical material containing amide was immersed in the bivalirudin-WSC solution for 1 hour to 48 hours, then use pH 7.4 PBS and rinse thoroughly with distilled water and dry to obtain the desired product.

The present invention acts as an anticoagulant by an anticoagulant material or device obtained by directly and specifically inhibiting thrombin activity.

The exact effect of the anticoagulant, the use of a safer method is simple and does not limit the material or body structure of the instrument.



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